Harbourfront Centre works with over 450 community organizations, and hosts more than 4,000 events a year in many disciplines such as theatre, dance, literature, music, film, visual arts and craft.

The project transformed the industrial space into a mixed-use building that included shops, restaurants, offices, and exclusive residential condos (it once was the home for Premier Mike Harris).

Artists who have performed at Harbourfront Centre: Celine Dion, Oscar Peterson, Robert Lepage, STOMP, Julio Iglesias, Spalding Gray, Philip Glass, Ann Murray, k.d.

The participating artists included Issey Miyake, Guy Laliberté, Philippe Starck, Frank Gehry, Lily Tomlin, Stephen Sondheim, Bernardo Bertolucci, Robert Rauschenberg, Harold Pinter, Joni Mitchell, Robert Lepage, Peter Gabriel, Quincy Jones, and Pina Bausch.

In 2004, Harbourfront Centre has hosted the Planet IndigenUS Festival, a multi-day celebration and global exploration of contemporary Indigenous civilizations.