Harleyville is a town in Dorchester County, South Carolina, United States.

[6] The St. Paul Camp Ground was added to the National Register of Historic Places in 1998.

[8] U.S. Route 178 passes through the center of town, leading northwest 31 miles (50 km) to Orangeburg and southeast 7 miles (11 km) to its terminus at U.S. Route 78.

According to the United States Census Bureau, the town has a total area of 1.2 square miles (3.0 km2), all of it land.

30.8% of all households were made up of individuals, and 16.4% had someone living alone who was 65 years of age or older.