SC 453 begins at an intersection with U.S. Route 178 (US 178; West Main Street) in Harleyville, Dorchester County.

It travels to the north-northeast and crosses over some railroad tracks just before an interchange with Interstate 26 (I-26).

It curves back to the northeast and passes Holly Hill Academy just before crossing Briner Branch.

The highway continues to the northeast, through rural areas and enters Eutawville.

Almost as soon as it enters town, it meets its northern terminus, an intersection with SC 45 (Branchville Highway/Eutaw Road).