[3] The podcast featured many guest appearances, including Game Grumps, Emily V. Gordon, Kumail Nanjiani, Greg Proops, Aubrey Plaza, Bobcat Goldthwait, Rob Schrab, Curtis Armstrong, Patton Oswalt, Jason Sudeikis, Dana Carvey, Felicia Day, Robin Williams, Mitch Hurwitz, Joel McHale, Rob Corddry, John Mayer, Eric Idle, Logic, and Steve Agee.

On March 8, 2014, a documentary about the podcast, also called Harmontown, premiered at the South by Southwest Film Festival.

The original premise of Harmontown began with Harmon's and Davis's attempts to discuss how to successfully eliminate the flaws of society and create a utopia (which they claimed could be addressed with the creation of a lunar colony) in front of a live audience.

Crittenden happened to be an audience member when Harmon and Davis asked for assistance from the crowd with how to play D&D.

From October 2017 to June 2018, the podcast was recorded without an audience due to permit issues at Starburns Studios.

Harmontown returned to live audience format in June of 2018 at Dynasty Typewriter at The Hayworth, in Westlake, LA.

Occasionally, special guests would serve as comptroller, including Mitchell Hurwitz, Bobcat Goldthwait, and—on the Harmontown movie tour—Gilbert Gottfried, Dino Stamatopoulos, Steve Agee, and LeVar Burton.