Harmony offers a large array of courses in regular, honor, and Advanced Placement.

Harmony offers Advanced Placement in Linguistics for English Language and English Literature, Advanced Placement in Math for Statistics and Calculus, Advanced Placement in Science for Biology, Environmental Science, Chemistry, and Physics, Advanced Placement in Social Studies for Human Geography, World History, U.S. History, Macroeconomics, and U.S. Government, and Advanced Placement in Languages for Spanish and French.

Along with Advanced Placement, Harmony also offers Dual Enrollment, provided by Valencia College, for all students.

Harmony High School is also a magnet school for Digital Video Production, Digital Media, Gaming and Simulation, Engineering, Agriscience, veterinary Assistance, and Fashion Design.

Harmony High School offers the following sports: