Harrisia tetracantha is a species of cactus found in Bolivia.

Harrisia tetracantha grows in a shrub-like to tree-like manner, is usually branched above the ground and reaches heights of up to 3 meters.

The single, strong, initially brownish central spine later becomes white to ash-gray.

[1] Harrisia tetracantha is widespread in the Bolivian departments of Cochabamba, Chuquisaca, Potosi, Santa Cruz and Tarija in dry scrub forest at elevations of 1200–2600 meters.

[3] David Richard Hunt placed the species in the genus Harrisia in 1987.