Harry Clayton (born 1904, date of death unknown) was an English professional footballer who played in several defensive positions.
The following month, Clayton joined his hometown team Nelson, who played in the Football League Third Division North.
He made his professional debut on 23 January 1926, deputising for Clement Rigg in the left-back position in the 1–2 defeat away at Southport.
In the summer of 1926, Clayton returned to the Lancashire Combination with Morecambe, where he played alongside fellow former Nelson defender Eddie Eastwood.
In early 1931, Clayton had a short spell with Central FC (Belle Vue), and later played for Bacup Borough.