The sale or marketing of the Hoxsey Method was banned in the United States by the FDA on September 21, 1960 as a "worthless and discredited" remedy and a form of quackery.
Hoxsey himself traced the treatment to his great-grandfather, who observed a horse with a tumor on its leg cure itself by grazing upon wild plants growing in the meadow.
[7][8] Among the claims made in his book, he purports his therapy aims to restore "physiological normalcy" to a disturbed metabolism throughout the body, with emphasis on purgation, to help carry away wastes from the tumors he believed his herbal mixtures caused to necrotize.
Dogged in many states by legal trouble for practicing medicine without a license, Hoxsey frequently shut down his clinics and reopened them in new locations.
[11] In 1950, Hoxsey submitted case histories of 77 patients to the National Cancer Institute (NCI), claiming that they were "fully documented with clinical records and pathological reports" and that they would demonstrate his treatment's effectiveness.
Hoxsey herbal treatments include a topical paste of antimony, zinc and bloodroot, arsenic, sulfur, and talc for external treatments, and a liquid tonic of licorice, red clover, burdock root, Stillingia root, barberry, Cascara, prickly ash bark, buckthorn bark, and potassium iodide for internal consumption.
During treatment, patients are asked to avoid consumption of tomatoes, vinegar, pork, alcohol, salt, sugar, and white flour products.
[7] In 2005, the cost of initial evaluation and treatment with Hoxsey Therapy at the Bio-Medical Center in Tijuana, Mexico was reported to be between $3,900 and $5,100, though this price did not include the recommended purchase of an unspecified number of dietary supplements and 3 years of return visits.
[12][15] Mildred Nelson, director of the Bio-Medical Center, has claimed an 80% success rate, and attributed treatment failures to a "bad attitude" on the part of the patient.
The University panel found that: For over one-half of the [cancer] patients from British Columbia, the result [of treatment with the Hoxsey method] has been either death or progression of the disease.
[12]The panel reported that in the one case of demonstrable cure, a patient with a skin cancer of the ear, Hoxsey's treatment had resulted in disfigurement which could have been avoided with standard surgical excision.
[12] The treatment gained wide press coverage in 2006 due to a court dispute between the family of Starchild Abraham Cherrix and Social Services of the State of Virginia.
On August 16, 2006, Circuit Judge Glen A. Tyler announced that both sides had reached an agreement that the parents did not act in a way that was medically neglectful.