Hartsville is the largest city in Darlington County, South Carolina, United States.

Hartsville is home to several major corporations including Sonoco Products Company, Duke Energy's H. B. Robinson Nuclear Generating Station, Novolex, and Stingray Boats.

The area surrounding Hartsville was once home to several Native American tribes, including the Pee Dee, Catawba, Chicora, Edisto, Sane, and Chicora-Waccamaw, who inhabited the region until European settlers arrived.

The town is named for Captain Thomas E. Hart, who eventually owned most of the land in the community.

James Lide Coker came to Hartsville in 1857 with plans to implement new farming methods he had learned at Harvard College.

Even with his own successes in business, Coker and his family were unable to convince other business owners in the area to build a railroad spur, so they decided to build their own, which became the Hartsville Railroad, completed in 1889.

The Town of Hartsville received its first charter on December 11, 1891, during a period of bustling economic activity and growth.

The number of days with measurable precipitation is 106, and the city receives about 46 inches (1,200 mm) of rainfall per year.

Major employers in the area include Sonoco Products Company, Nucor Corporation, Carolina Pines Regional Medical Center, Novolex, Stingray Boats, North Industrial Machine, and Duke Energy's H. B. Robinson Nuclear Generating Station.

Job growth over the next decade is expected to be approximately 27.4% which is significantly lower than the US average of 33.5%.

[38] City Hall is located at 100 E Carolina Avenue in a building previously occupied by the Bank of America.

The organization seeks to build a vibrant downtown in Hartsville, focusing on thriving businesses, entertainment, recreating and historic preservation.

It follows the Main Street "Four Point Approach" of organization, promotion, design, and economic restructuring.

[39] Main Street Hartsville administers a Sign and Paint grant for local businesses.

It offers a four-year program that emphasizes a practical application of the liberal arts, as well as hands-on and discussion-based learning within and beyond the classroom.

Florence–Darlington Technical College, based in nearby Florence, South Carolina, maintains a satellite campus in Hartsville.

The Hartsville Messenger, an affiliate of SCNow, is the local newspaper, with The State serving as a source for statewide news.

However, in newly developed sections of the city, such as around Hartsville Crossing, the road layout is less orthodox.