North Hartsville is a census-designated place (CDP) in Darlington County, South Carolina, United States.

[6] It is part of the Florence Metropolitan Statistical Area and the Hartsville Urban Cluster.

North Hartsville is located in northwestern Darlington County at 34°23′45″N 80°4′13″W / 34.39583°N 80.07028°W / 34.39583; -80.07028 (34.395845, -80.070153).

[7] It is bordered to the south, across Prestwood Lake and Black Creek, by Hartsville, the largest city in Darlington County.

24.4% of all households were made up of individuals, and 8.3% had someone living alone who was 65 years of age or older.