The group rose to prominence during Marvin's thirty-two-year tenure, receiving critical acclaim through recordings, international tours, and numerous invited appearances at professional conferences.

Andrew Clark became Collegium's third conductor in 2010 and has led the ensemble in performances of Bach's Saint Matthew Passion, Handel's Israel in Egypt, Mozart's Requiem, Haydn's The Creation, Rachmaninoff's All-Night Vigil (Vespers), and Arvo Pärt's Saint John Passion, as well as in appearances at Boston's Jordan Hall, the Metropolitan Museum of Art in New York, Salzburg Cathedral, and St. Stephen's Cathedral in Vienna.

[5] On March 7, 2020, Collegium held a closed concert to an empty Sanders Theater due to mounting fears from administration at Harvard University about COVID-19.

In the 2015–2016 academic year, Collegium sang Tigran Mansurian's Requiem with the Boston Modern Orchestra Project, in a memorial concert commemorating the 100th anniversary of the Armenian genocide.

In the spring of 2016, Collegium performed at the Boston ACDA Convention and sang the fusion-oratorio Considering Matthew Shepard under the direction of its composer, Craig Hella Johnson.

In collaboration with the Boston Children's Chorus and Harvard Dance Project, Collegium performed a concert of American battle hymns.