The Hasinai Confederacy (Caddo: Hasíinay[2]) was a large confederation of Caddo-speaking Native Americans who occupied territory between the Sabine and Trinity rivers in eastern Texas.

Today, their descendants are enrolled in the Caddo Nation of Oklahoma and the Natchitoches Tribe of Louisiana.

[3] Variants of Hasinai include: Hasini, Asenai, Asinai, Assoni, Asenay, Cenis, Senis, Sannaye,[3] Asinaiz, Asinayes, Assinais, Azinais, Azinays.

[4] When the Spanish and the French encountered the Hasinai in the 1680s, they were a centrally organized chiefdom under the control of a religious leader, known as the Grand Xinesi.

[7] Over the next 250 years, the population of these Caddoan-speaking peoples was severely reduced by epidemics of endemic diseases carried by Spanish and French colonists and spread through indigenous trading networks.