He served during the presidencies of Megawati Sukarnoputri and Susilo Bambang Yudhoyono.

A lawyer by training and a diplomat by choice, Wirajuda has held several important posts including Director-General of Political Affairs of the Ministry of Foreign Affairs (July 2000 – August 2001), Ambassador and Permanent Representative to the United Nations and other international organizations in Geneva (December 1998 – July 2000), Ambassador Extraordinary and Plenipotentiary to Egypt (October 1997 – December 1998), and Director of International Organizations of the Department of Foreign Affairs (1993–1997).

[2] In 2007 he chaired the first Indonesia-UK forum alongside British foreign minister Margaret Beckett.

During his diplomatic career, Wirajuda also assisted in the establishment of the Indonesian National Commission on Human Rights (Komnas HAM).

[5] Since 2023, Wirajuda is serving as chairman of the Study Centre on Indonesian Nationhood (PSKI) and dean at the School of Law and International Studies at Prasetiya Mulya University.