Haut-Sassandra is currently divided into four departments: Daloa, Issia, Vavoua, and Zoukougbeu.

The region is traversed by a northwesterly line of equal latitude and longitude.

In 2000, Gagnoa Department was split off from Haut-Sassandra and combined with Oumé Department from Marahoué Region to form Fromager Region.

As part of the 2011 administrative reorganisation of the subdivisions of Ivory Coast, Haut-Sassandra was converted into a second-level administrative region and became part of the new first-level Sassandra-Marahoué District.

[5] No territorial changes were made to Haut-Sassandra as a result of the reorganisation.