[1][2] The latter two – known collectively as comedy duo Jake and Amir – built upon the success of their podcast If I Were You to launch the network, with the show serving as its flagship program.

[9] Host Ian Karmel – with frequent co-hosts Sean Jordan and David Gborie – conducts a fantasy draft for pop culture topics with guests.

[13] John-Michael Bond of The Daily Dot praised All Fantasy Everything as one of the top comedy podcasts of 2018, describing it as "a refreshing change of pace".

[18] Corked is a scripted "true" crime comedy set in Napa Valley about a brash winemaker with a secret past, his missing girlfriend, and a jilted roughneck from Louisiana who pulls an investigative journalist into a mystery that quickly consumes his life and career.

The show was written, directed, and edited by Giancarlo Fiorentini and Jonathan Grimm, and stars Anthony Gioe, Whitmer Thomas, Jon Gabrus, Betsy Sodaro, Natalie Palamides, Dan Klein, Mary Holland, Josh Ruben, Lou Wilson, and Ally Beardsley.

[19] Lauren Passell of Lifehacker named Corked one of the funniest fiction podcasts, stating that the show "mixes silliness with a traditional true crime format, making it a pleasing surprise for anyone who is familiar with public radio investigations".

[30] Hosts and friends, Mike Falzone and Steve Zaragoza tackle a different topic each week and – once monthly – present a movie commentary episode labelled "The Commentarium".

The podcast has featured episodes with Kevin Hart,[34] Ray Romano,[35] Nick Kroll,[36] Will Forte,[37] Bo Burnham,[38] Jimmy Fallon,[39] John Mulaney,[40] Jerry Seinfeld,[41] and Weird Al Yankovic.

[53] Sam Tabachnik of The Washington Post has written of If I Were You that it exemplifies how Jake and Amir "have their fingers firmly on the pulse of the digital comedy scene",[54] while Kayla Culver of The Concordian likened the podcast to "listening to two best friends having a hilarious conversation on the couch next to you".

[58] Each episode, Harvard Sailing Team members and comedians Billy Scafuri and Adam Lustick discuss their history and relationship with a single topic.

[59] CollegeHumor alumni Brian K. Murphy, Emily Axford, Jake Hurwitz and Caldwell Tanner present this Dungeons & Dragons actual play podcast.

The first main campaign follows the adventures of "the Band of Boobs" – composed of Axford, Hurwitz, and Tanner's respective characters: Moonshine Cybin, a Crick elf druid; Hardwon Surefoot, a human fighter raised by dwarves; and Beverly Toegold V, a teenaged halfling paladin.

[64]| [65] A weekly show hosted by Reilly Anspaugh and Alfred Bardwell-Evans (2020-2022: Geoffrey James) that blends conversation and improv comedy based on the most absurd reviews on the internet.

Ryan "Video Game Attorney" Morrison, Austin Hoffman, and Ali Rothman, analyze and discuss topics around the intersection of law and technology.

[67] Branson Reese and his jester's retinue, Christopher Hastings, Carly Monardo, Tim Platt, Joe Lepore, and Ali Fisher, buck and bumble through the magical backwater world of Cordelia.

[69] Since relaunching under the Headgum network, Seek Treatment has featured guests such as Dylan Mulvaney, Robby Hoffman, and Kate Berlant.

[70][71][72] Erin Keif, Waleed Mansour, Elizabeth Andrews, Sean Coyle, and Ben Briggs star in a weekly podcast which blends sitcoms with Dungeons & Dragons.

[76] The Complete Guide to Everything is a weekly podcast that delves in to a wide array of topics, driven by hosts Tom Reynolds and Tim Daniels' quests to make the world a more informed place.

[84] Headgum staff members/racing enthusiasts Casey Donahue, Marika Brownlee, Andrew Pile, Jake Hurwitz and Geoffrey James host this "F1 Podcast for the casual fan".

Writers of a humorous advice book of the same name, Laura Lane and Angela Spera meet weekly to analyze and explain real-life dating disasters.

This variety show includes actual play campaigns, interviews, gameplay tips and discussion of Black experience within nerd culture.

[88] Each episode identical twins Dave and Jeff Rosenberg (CollegeHumor/Funny Or Die alum) alongside Queen Ana Merida, comically design get-rich-quick schemes and inventions.

Each week, Andrew Jupin, Stephen Sajdak, Eric Szyszka and Chris Cabin force themselves to watch and review infamous movies and box-office flops.

[92] There are also hundreds of bonus Patreon episodes which cover various TV shows such as Melrose Place; Beverly Hills, 90210; and Star Trek; as well as full length commentaries for films.

Hosts Alesia, Fatima, Aurelia, and Ramou provide their opinions on a diverse range of topics, with specific attention to the perspective and representation of people of color.

[101] Actor and comedian Conor Ratliff tries to solve a "very stupid mystery":[102] after being cast for a small roll in an episode of HBO's Band of Brothers directed by Tom Hanks, the latter reportedly said he had "dead eyes" and had him fired.

The podcast has featured guest appearances from a wide array of talents including the likes of: Kiernan Shipka;[112] Moby;[113] Steve Aoki;[114] Paul Stanley;[115] Kelis;[116] The Wombats;[117] Jason Lee;[118] Wolfgang Puck;[119] Doug Benson;[120] Questlove;[121] Alt-J;[121] Portugal.

The Man;[122] Harley Morenstein;[123] Eddie Huang;[124] Jon Favreau;[125] Fall Out Boy;[126] Curtis Stone;[127] Tenacious D;[128] Rachael Ray;[129] and Action Bronson.

The podcast featured appearances by Lin-Manuel Miranda,[143] Randall Park,[144] Joe Manganiello,[145] Hasan Minhaj,[146] and Rachael Leigh Cook.

The podcast was also expanded to feature contributions from musician and music theorist Rob Moose, which was referred to as the show's "weatherman" segment.