[4] She made several guest appearances in such comedy series as 30 Rock (2012), Family Guy (2016), Transparent (2016–2017), The Good Place (2019), Brooklyn Nine-Nine (2019–2021), and The Simpsons (2019).

"[7] She then took classes at the Upright Citizens Brigade, starting improv and sketch comedy in June 2008, the same month that her father died.

[9] She tours the United States doing stand-up comedy and regularly performs improv with Upright Citizens Brigade in Los Angeles.

Each episode features three home bakers with a "terrible track record" attempting to recreate extremely complicated pastries for a $10,000 prize.

[16] Byer received a nomination for the Primetime Emmy Award for Outstanding Host for a Reality or Competition Program four times (2020, 2021, 2022, and 2023).

[17] In 2016, MTV premiered Loosely Exactly Nicole, a scripted, single-camera comedy written and starring Byer, based on her life.

[4] Madeleine Davies at Jezebel described the show's premise as a "comedic look on [Byer's] life as a black actress struggling to make it in Hollywood.

[5] Each episode features a guest, typically another comedian, with whom Byer converses openly about her limited dating history, past sexual experiences, and frustration with being single.

Past guests include her very close friend Sasheer Zamata, Emily Heller, and Brooks Wheelan.

Guest episodes have included such pairs such as actresses June Diane Raphael and Casey Wilson, drag queens Katya Zamolodchikova and Trixie Mattel, and internet personalities Keith Habersberger and Zach Kornfeld of The Try Guys.

Past guests have included John Gemberling, Demi Adejuyigbe, Paul F. Tompkins, and Betsy Sodaro.

The third season explored Tyler Perry's body of work and the fourth goes through the Fast & Furious franchise, with a new co-host, Jon Gabrus as a guide.

"[29] The title began as a joke hashtag on Instagram, making fun of the way people often comment on photos of fat women wearing relatively little clothing as, 'You're so brave.

'[29] In 2013, Byer and Sasheer Zamata created and starred in a web series called Pursuit of Sexiness which was produced by Upright Citizens Brigade.

[31] On The Ringer, Allison P. Davis described Byer's comedy: "Most easily compared to a raunchier Retta with a hint of Ilana Glazer's madcap energy.

She's mouthy, vulgar, a little bit goofy, relatable but ridiculously charming, and not afraid to infuse her broad comedy with a confident sexuality.