Most issues featured a number of short comics stories, as well advice columns, text pieces, and filler.

The long-running feature "3 Girls—Their Lives—Their Loves", drawn by Jay Scott Pike and inked by Russ Jones, ran in Heart Throbs from 1966–1970.

The company closed in 1956, selling most of its assets to National Periodical Publications (now known as DC Comics).

Starting with its first issue as publisher, DC ran the regular text feature "It Happened in Hollywood" in Heart Throbs until the early 1960s.

Starting with issue #102 (June/July 1966), Heart Throbs began the long-running serial "3 Girls—Their Lives—Their Loves".

During the Quality Comics period, Hearth Throbs featured Marilyn Minton's "Advice on Love Problems".

For a while Mort Drucker supplied illustrations for regular one-page fillers after the title's acquisition by DC.

[2] In 1999, the DC Comics imprint Vertigo published a four-issue limited series titled Heartthrobs, which spoofed Heart Throbs in an R-rated manner.

Heartthrobs featured satirical adult-oriented stories by such creators as Brian Azzarello, Frank Quitely, Ilya, Bob Fingerman, and Richard Corben.