[5][6] This protein is a member of the serpin superfamily of serine proteinase inhibitors.

Antibodies directed to this protein have been found in patients with rheumatoid arthritis.

[8] Research published in 2023 indicates a potential role of HSP47 regarding deep vein thrombosis.

Research has shown that HSPs have a role in fibrotic diseases.

During the process of fibrosis, HSP47 is expressed and is involved in the production of collagen.