The facility, which was designed by John Eaglesham (1855–1922),[1][2] opened as the Burgh Fever Hospital in June 1905.

[3] It joined the National Health Service in 1948 and a large outpatients' department was built on an adjacent site in 1962.

[3] After services transferred to the new Ayr Hospital,[4] the inpatient facilities at Heathfield Hospital closed in 1991 and the buildings were subsequently demolished.

[3] The out‑patients' department became known as the Heathfield Clinic and continued to provide services until 2015 when it also closed and was also subsequently demolished.

[3] The regional headquarters for the Scottish Ambulance Service serving south-west Scotland (Ayrshire, Dumfries and Galloway) and west South Lanarkshire remains located on an adjacent site in Maryfield Road.