[5] Elements often discussed as toxic include cadmium, mercury and lead,[6] all of which appear in the World Health Organization's list of 10 chemicals of major public concern.
The International Union of Pure and Applied Chemistry (IUPAC), which standardizes nomenclature, says the term “heavy metals” is both meaningless and misleading".
[9] The IUPAC report focuses on the legal and toxicological implications of describing "heavy metals" as toxins when there is no scientific evidence to support a connection.
[5] Metals with multiple toxic effects include arsenic (As), beryllium (Be), cadmium (Cd), chromium (Cr), lead (Pb), mercury (Hg), and nickel (Ni).
[14] Elements that are nutritionally essential for animal or plant life but which are considered toxic metals in high doses or other forms include cobalt (Co), copper (Cu), iron (Fe), magnesium (Mg), manganese (Mn), molybdenum (Mo), selenium (Se), and zinc (Zn).
[13] Toxic metals are found naturally in the earth, and become concentrated as a result of human activities, or, in some cases geochemical processes, such as accumulation in peat soils that are then released when drained for agriculture.
[27] Toxic metals enter plant, animal and human tissues via air inhalation, diet, and manual handling.
[28] Motor vehicle emissions are a major source of airborne contaminants including arsenic, cadmium, cobalt, nickel, lead, antimony, vanadium, zinc, platinum, palladium and rhodium.
[35] Toxic metals "can bind to vital cellular components, such as structural proteins, enzymes, and nucleic acids, and interfere with their functioning".
Broadly, long-term exposure to toxic heavy metals can have carcinogenic, central and peripheral nervous system, and circulatory effects.
In that year, Wanklyn and Chapman speculated on the adverse effects of the heavy metals "arsenic, lead, copper, zinc, iron and manganese" in drinking water.
[41] The following sections provide historical thumbnails for the "classical" toxic heavy metals (arsenic, mercury and lead) and some more recent examples (chromium and cadmium).
), a Greek geographer and historian,[42] wrote that only slaves were employed in realgar and orpiment mines since they would inevitably die from the toxic effects of the fumes given off from the ores.
[45] The first emperor of unified China, Qin Shi Huang, it is reported, died of ingesting mercury pills that were intended to give him eternal life.
[48] Outbreaks of methylmercury poisoning occurred in several places in Japan during the 1950s due to industrial discharges of mercury into rivers and coastal waters.
In 22 documented cases, pregnant women who consumed contaminated fish showed mild or no symptoms but gave birth to infants with severe developmental disabilities.
"[55] During the Mongol period in China (1271−1368 AD), lead pollution due to silver smelting in the Yunnan region exceeded contamination levels from modern mining activities by nearly four times.
In 2013, the World Health Organization estimated that lead poisoning resulted in 143,000 deaths, and "contribute[d] to 600,000 new cases of children with intellectual disabilities", each year.
The source of the contamination was attributed to "a combination of dilapidated drinking water infrastructure, including lead jointed pipelines, end-of-life polyvinyl chloride pipes and household plumbing".
The town was only notified three days after the release and the accident sparked a major public controversy, with Orica criticised for playing down the extent and possible risks of the leak, and the state Government attacked for their slow response to the incident.
The origin of these symptoms was not clear; possibilities raised at the time included "a regional or bacterial disease or lead poisoning".
Vitamin and mineral supplements are sometimes co-administered for this reason[72][73] Soils contaminated by heavy metals can be remediated by one or more of the following technologies: isolation; immobilization; toxicity reduction; physical separation; or extraction.