Helen C. Peirce School of International Studies first opened its doors in September 1915.

The school was named in honor of Helen Caroline Peirce; the founding president of the Lake View Women's Club.

The school was originally named "Helen C. Peirce" but in 1993, it was selected to participate in the Chicago Board of Education Specialty School Program and was renamed the Helen C. Peirce School of International Studies.

In 2010 Perice officially became a part of the IB (International Baccalaureate) programme MYP (Middle Years Programme 6th-8th grade)

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