Helmut Sies

He was the first to demonstrate the existence of hydrogen peroxide as a normal attribute of aerobic life in 1970,[1] and he introduced the concept of Oxidative stress[2] in 1985.

In 1967 he received his medical doctorate summa cum laude at Munich, where he worked at the Institute of Physiological Chemistry from 1968.

[4] Investigating biological redox reactions,[5] he identified hydrogen peroxide as a normal constituent of aerobic life in eukaryotic cells.

[1] This finding led to developments that recognized the essential role of hydrogen peroxide in metabolic redox control.

Further research included studies on glutathione,[6] toxicological aspects (the concept of "redox cycling"),[7] biochemical pharmacology (Ebselen),[8] nutritional biochemistry and micronutrients (selenium, carotenoids, flavonoids), and the concept of "Oxidative Stress".