[3] Guardant Health was founded to pioneer non-invasive liquid biopsy approaches for cancer diagnosis, monitoring, personalized medicine treatment, and research.

[8] Eltoukhy’s doctoral thesis, “An integrated system for de novo DNA sequencing” research was completed in the laboratory of Abbas El Gamal, for a project that combined genomics and sensor engineering.

[14][16] In 2012, Eltoukhy and AmirAli Talasaz co-founded Guardant Health, established to "forge a new frontier" in cancer detection and treatment using artificial intelligence[17] and a big data approach.

[4][26][27] The test uses a combination of genomics and signal processing innovations to simultaneously profile the mutational signature of several (54 at time of product launch; 74 as of 2019)[28] circulating tumor DNA genes in patient blood samples.

[29][31][34] In 2017, a venture capital funding round led by SoftBank raised $360 million,[26] allowing Guardant Health to expand operations globally[35] and continue to focus on accelerating progress towards early cancer detection.

The case, presided over by multiple judges, including Sharon K. Cho, Don R. Franchi, and Susan Greenberg, remains active with pending matters as of the latest update in October 2024.

Both Carson and Helmy Eltoukhy are represented by their respective attorneys, who continue to navigate the complexities of this family court case as they work towards finalizing the separation.

[55] In December 2024, Eltoukhy was announced as co-Chairman of English football club Sheffield United alongside fellow American businessman Steve Rosen.