The original hospital in Hemel Hempstead was established when Sir Astley Cooper converted a row of cottages at 130–136 Piccotts End to create an infirmary in 1827.

[1] The medical team moved to larger premises, acquired with funding from Sir John Sebright, 7th Baronet, at Cheere House at the bottom of Hillfield Road in 1832.

[1] The main block of the current hospital, then known as the West Hertfordshire Infirmary, was built further up Hillfield Road and was opened by Princess Mary of Teck in 1877.

[2] The Marnham Maternity Wing, which was started in 1926 when a foundation stone was laid by the Prince of Wales just north of the main block, opened in 1929.

[7] Large parts of the hospital site are currently mothballed and not actively used for healthcare provision, following the removal of the Accident & Emergency department in 2006.