[2] Chambers played in Nashville with Doc Banks in 1932, then with Jack Jackson's Pullman Porters, Speed Webb, Zack Whyte, and Al Sears in Kentucky.
After two years with Tiny Bradshaw in the middle of the 1930s, Chambers moved to New York City,[1] where he played with Chris Columbus at the Savoy Ballroom in 1939-40.
[1] Later in the 1940s, he worked with Don Redman, Sy Oliver, Lucky Millinder, and Count Basie; in the 1950s he spent time with Cab Calloway, Doc Cheatham, Duke Ellington, and Mercer Ellington.
After joining Ray Charles's band from 1961 to 1963, Chambers played with Basie again until 1966.
[1] Chambers finally played with Edgar Battle, shortly before his own death from a heart attack, in 1967 in New York City.