Hendron is an unincorporated community and census-designated place (CDP) in McCracken County, Kentucky, United States.

[3] Hendron is located at 37°2′16″N 88°38′42″W / 37.03778°N 88.64500°W / 37.03778; -88.64500 (37.037800, -88.644889)[4] and borders the southern edge of the city of Paducah.

The original community of Hendron is in the northeast part of the CDP at Old Mayfield Road,[5] north of where it crosses Interstate 24.

[6] Hendron is bordered to the west by the CDP of Massac, and the unincorporated community of Lone Oak along US 45 is split between the two CDPs.

26.9% of all households were made up of individuals, and 9.6% had someone living alone who was 65 years of age or older.