It is the northern terminus of the S-Bahn line S25 as well as a station for regional passenger trains and freight services.

As a consequence of World War II and the German partition, the station was close to the border with West Berlin.

At the intersection of the two routes an interchange station Hennigsdorf Nord was constructed, facilitating quick and easy transfer of passengers between trains due to its conception on two levels (Turmbahnhof).

The S-Bahn station was reopened on 15 December 1998 when the section between Tegel and Hennigsdorf was taken into service again, initially only with a single track.

The states of Berlin and Brandenburg investigate the feasibility of extending the Regional-Express route from Wittenberge and Wittstock along the Kremmener Bahn to Berlin-Gesundbrunnen station.

Until 1983, S-Bahn trains still operated between Hennigsdorf and Velten, running about twice an hour, albeit without a fixed timetable.