Duke Henry IV of Brunswick Grubenhagen (1460 – 6 December 1526, Salzderhelden, now part of Einbeck) was a member of the Guelph dynasty and was Prince of Brunswick-Grubenhagen.
Since he was a minor, he was under the guardianship of his uncle, Albert II until he came of age in 1479.
After Albert II died in 1485, Henry became guardian of his underage cousin Philip I.
When Henry died childless in 1526, Philip I inherited his territory and thereby reunited all parts of Grubenhagen.
Henry married on 26 August 1494 in Einbeck with Elisabeth of Saxe-Lauenburg (died: after 7 April 1542), the daughter of Duke John V of Saxe-Lauenburg and Dorothea of Brandenburg.