The Raid on Puerto del Príncipe was a military event which took place during the latter stage of the Anglo-Spanish War between March and April 1668 on the Spanish island of Cuba.

Some 700 Buccaneers in twelve ships led by Captain Henry Morgan landed in the Gulf of Santa María and marched to capture the inland town of Puerto del Príncipe.

In 1667 diplomatic relations between the kingdoms of England and Spain were worsening, and rumours began to circulate in Jamaica about a possible Spanish invasion.

Henry Morgan, who had been in charge of the Port Royal militia took over further privateering expeditions as Admiral in Chief of the Confederacy of Buccaneers.

[9] Morgan ordered his fleet to rendezvous off southern Cuba, which including such notable commanders as John Morris and Edward Collier.

[10] Morgan's fleet arrived off Havana in mid-March, but on discovering that it was heavily defended, they instead sailed to Santiago de Cuba.

[10] Morgan did not approach the town directly as the Spanish governor of Puerto del Príncipe was hoping, so marched his men off via the dense jungle.

[12] The remnants attempted to escape into the nearby forest but they and their native allies lost most of their force, some 700 were either killed, wounded or captured.

[15] Two days later however Morgan was given a captured negro slave who had with him some letters from the Governor of Oriente Province, Pedro Bayona Villanueva forbidding any payments to be made and that help would be on the way with a relief force.

[20] When Morgan reported the taking of Puerto Principe to Modyford, he informed the governor that they had evidence that the Spanish were planning an attack on British territory: "we found seventy men had been pressed to go against Jamaica ... and considerable forces were expected from Vera Cruz and Campeachy ... and from Porto Bello and Cartagena to rendezvous at St Jago of Cuba [Santiago]".

[22] Morgan with the casked meat on board his fleet was now well supplied for his next venture - he had his eyes set on a bigger prize, the port town of Porto Bello.

The English repelled a Spanish counter sent by the Governor of Panama and having then received a large ransom before leaving for Jamaica unmolested.