Henry Radclyffe, 2nd Earl of Sussex, KG (also spelt "Radcliffe") (1507 – 17 February 1557) was a son of Robert Radclyffe, 1st Earl of Sussex and his wife Elizabeth Stafford, Countess of Sussex.

They had two sons: The Complete Peerage gives the date of death for his first wife as 18 September 1534.

Burke's Peerage agrees on the date but changes the year to 1537.

The marriage resulted in a divorce or annulment in 1555, but they had three known children: On 27 November 1542, his father died and Henry succeeded him as Earl of Sussex.

His second cousin Mary I created him a Knight of the Garter in 1554, alongside the later Philip II of Spain, Emmanuel Philibert, Duke of Savoy and William Howard, 1st Baron Howard of Effingham.