Henry Ussher (c.1550 – 2 April 1613) was an Irish Protestant churchman, a founder of Trinity College Dublin, and Church of Ireland Archbishop of Armagh.

In January 1584 the lord deputy, Sir John Perrot, received instructions to draw up proposals for the conversion of St. Patrick's into a college.

The matter was next taken up by the Dublin corporation, who offered (21 January 1591) the site of the Augustinian priory of All Saints', with land worth £20 a year.

On the death (2 March 1595) of John Garvey, his brother-in-law, Ussher was appointed archbishop of Armagh (patent 22 July), and was consecrated in August 1595.

A story told by Henry Fitzsimon, to the effect that Ussher had written against Cardinal Bellarmine, and his wife had burned the manuscript, was embellished by Pierre Bayle.

Ussher died at his episcopal palace at Termonfechin on Easter day, 2 April 1613, and was buried at St. Peter's, Drogheda.

His youngest son Robert Ussher was Provost of Trinity College Dublin 1629-1634 and Bishop of Kildare 1635-42.