[7][8] Eagle-Picher placed a massive zinc smelting facility in the Spelter City area of town, which continued through the 1960’s.

Besides Anchor Glass, current employers include the international oilfield-services company Shawcor;[10] Henryetta Pallet, a regional wood pallet manufacturer;[11] and, G&H Decoy, a waterfowl decoy manufacturer since 1934.

[12] On May 1, 2023, seven people were killed in a mass murder in Henryetta, allegedly by Jesse McFadden, found as one of the deceased.

[5] Henryetta is at the crossroads of Interstate 40, being a major east–west interstate highway through the south-central portion of the United States, and U.S. Route 75, being a major north–south highway currently extending from Noyes, Minnesota on the Canada–United States border south to Dallas, Texas.

[18] Henryetta is served by the KI BOIS Area Transit System ("KATS"), a low-cost public bus/van service established in 1983 to help communities, primarily in southeast Oklahoma, by providing access to Senior Citizen centers, groceries, medical services, and jobs.

[22] Just south of town is Nichols Park, developed between 1938 and 1941 by the Civilian Conservation Corps and the National Park Service, which is over 300 acres in size, and includes the 17 acre Nichols Lake offering fishing opportunities.

[23] The park hosts many outdoor activities such as disc golf, baseball, all-terrain vehicle off-road trails, hiking trails, several playgrounds, multiple covered shelters for picnicking, primitive campsites, and large open fields for events.

In June 2022, Nichol's park was the site of the town's Highway to Henryetta event.

Amenities include boat ramps, docks, primitive campsites, picnic areas, and outdoor grills.

[26] Both the Hugh Henry House on N. 3rd St., and Nichols Park located 1.9 miles south of the junction of Lake Rd.

and Main St., are included on the National Register of Historic Places listings in Okmulgee County, Oklahoma.

[29] Henryetta is notable in its theatrical performances, most of which is done by the drama team of its local high school.