Preston is an unincorporated community located in Okmulgee County, Oklahoma, United States.

Later on, as the oil industry quieted in Preston, it served as a station for restocking trains and running cattle trails, loading water from Frisco Lake.

[citation needed] It currently has two schools, three churches, a single gas station, feed store, a heating and air company, and a hair salon, as well as a fire protection business and the offices of Oklahoma Rural Water District No.

Preston is served by U.S. Route 75,[6] a major national north/south artery for much of its length, currently running from the Canada–US border at Noyes, Minnesota to Dallas.

[7] Preston is also on Old Highway 75, being the previous two-lane alignment of US-75 running north to Beggs and south to Okmulgee.