[5] It was named in honour of Edward Henty, a British colonist regarded as the first permanent European settler of the Port Phillip District (in what later became the Colony of Victoria), in the town eventually named Portland.

It continues south on its own alignment until it eventually terminates at the intersection with Madeira Packet Road in the southern suburbs of Portland.

[10] The passing of the Highways and Vehicles Act of 1924[11] provided for the declaration of State Highways, roads two-thirds financed by the State government through the Country Roads Board.

[13] The southern end of the highway through Portland was changed in January 1987: from New and Percy and Gawler Streets terminating at the intersection of Gawler, Cliff and Bentick Streets in central Portland, to its current alignment along Port Road and the southern section of Portland-Nelson Road to the intersection with Wellington Road in Portland's southern suburbs.

[14] Henty Highway was signed as State Route 107 between Portland and Lascelles in 1986;[15] with Victoria's conversion to the newer alphanumeric system in the late 1990s, this was replaced by route A200 between Portland and Horsham, and B200 between Horsham and Lascelles.