Loddon Valley Highway runs roughly north-west from Bendigo to Kerang.

[5] It constitutes part of the direct route from Melbourne to the popular Murray River holiday areas around Swan Hill.

Loddon Valley Highway commences at the intersection with Murray Valley Highway just south of the fringes of Kerang and heads in a southerly direction as a dual-lane single carriageway rural highway, running parallel to the Loddon River a short distance to the west of the road for much of its length.

It continues south through Durham Ox until it reaches Serpentine, where it veers more to the south-east away from the river course, passing through the hills around Eaglehawk on the outskirts of Greater Bendigo, before it eventually terminates at the intersection with Calder Highway in Ironbark, in the north-western suburbs of Bendigo.

The passing of the Road Management Act 2004[9] granted the responsibility of overall management and development of Victoria's major arterial roads to VicRoads: in 2004, VicRoads re-declared the road as Loddon Valley Highway (Arterial #6630), beginning at Murray Valley Highway at Kerang and ending at Calder Highway in Ironbark, Bendigo.