Omeo Highway is a 163 kilometre rural highway in eastern Victoria, Australia, connecting Tallangatta on Lake Hume in north-east Victoria to Bairnsdale in East Gippsland,[5] over parts of the Victorian Alps.

There is some CB repeater coverage including UHF Ch1 (Mitta), and other traffic and log trucks on Ch 40.

As probably one of the most impressive scenic routes in Australia, there are excellent views along most of the road, making it very popular with tourists.

Due to the winding nature of the road along Omeo Highway, it is a common place for large groups of motorcycles to go riding.

With Victoria's conversion to the newer alphanumeric system in the late 1990s, the remainder of the highway was assigned route C543.