Herbert Hice Whetzel (September 5, 1877 – November 30, 1944) was an American plant pathologist and mycologist.

In 1914 he married Lucy's sister Bertha A. Baker, and they raised the children together in Ithaca, New York.

[3] His students included M. F. Barrus and Charles Chupp, who both went on to teach at Cornell and who shared Whetzel's conviction of the importance of extension work[2] as well as Carlos E. Chardón, who became a government minister and Chancellor of the University of Puerto Rico.

Whetzel studied sclerotium-producing cup fungi, and published a monograph of genera in the family Sclerotiniaceae.

He was a charter member of the American Phytopathological Society, authored more than 300 publications, and was instrumental in founding and developing the Cornell Plant Pathology Herbarium (CUP),[4] where his fungus collections are stored.