[2] Over the next twenty years several "tent" hospitals were constructed on the site, each dedicated to treating a specific infectious disease—scarlet fever, diphtheria and tuberculosis.

[2] By the mid 1920s Detroit voters approved a $3-million bond issue,[1] to build a brick and cement hospital.

As a result, in 1958, the Rehabilitation Institute moved to a newly built hospital at the Detroit Medical Center.

By the early 21st century the Kiefer was acting almost entirely as a public health facility, dispensing free vaccinations.

With the City of Detroit was facing bankruptcy, the mayor, David Bing, decided that the one million dollar maintenance cost of the aging building could not be afforded.

Bing closed the hospital, transferring its public health services to a private nonprofit which operated throughout the city from neighborhood facilities.