1JMA, 2AW2, 4FHQ, 4RSU8764230979ENSG00000273936ENSG00000157873ENSMUSG00000042333Q92956Q80WM9NM_001297605NM_003820NM_178931NP_001284534NP_003811NP_849262Herpesvirus entry mediator (HVEM), also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), is a human cell surface receptor of the TNF-receptor superfamily[5][6][7][8] encoded by the TNFRSF14 gene.

The protein encoded by this gene is a member of the TNF-receptor superfamily.

The cytoplasmic region of this receptor was found to bind to several TNF receptor associated factor (TRAF) family members, which may mediate the signal transduction pathways that activate the immune response.

[16] This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry.

[7] This article incorporates text from the United States National Library of Medicine, which is in the public domain.