Hesperocallis is a genus of flowering plants that includes a single species, Hesperocallis undulata, known as the desert lily or ajo lily.

It is found in the desert areas of southwestern North America, in Northwestern Mexico, California, and Arizona.

In the APG III system, adopted here, Hesperocallis is placed in the family Asparagaceae, subfamily Agavoideae, since recent molecular systematic studies (Pires et al. 2004) have confirmed a close relationship with Agave.

[2] As with many of the 'lilioid monocots', prior to the use of molecular evidence in classification, it was placed in the Liliaceae.

The bulbs of the desert lily are eaten by native peoples.