Queen Hetepheres II may have been one of the longest-lived members of the royal family of the Fourth Dynasty of Egypt, which lasted from ca.

During the reign of Khufu, Hetepheres II married her brother, the Crown Prince Kawab,[2] with whom she had at least one child, a daughter named Meresankh III.

The marriage of her daughter, Meresankh III, to her late second husband's successor Khafre made Hetepheres II the mother-in-law of the new king.

A mark of her affection for Meresankh III may be seen in the fact that Hetepheres II had her own mastaba in the eastern cemetery of Giza converted into a tomb for her daughter's use.

It has been suggested her subsequent marriage to Djedefre was honorary in nature and done in order to maintain her position at court.