Heustreu is a municipality in the district of Rhön-Grabfeld in Lower Franconia in Germany.

Heustreu is situated in the Main-Rhön region in the very north of Lower Franconia.

Heustreu was first mentioned in 1057 when a Polish princess gave the village as a present to the diocese of Würzburg.

The document in which this donation was certified is seen as the founding date of the village, although there might have been settlements on the soil at earlier times.

Most of them work in the nearby city of Bad Neustadt, in which Siemens, Preh and the Rhön Klinikum AG are the biggest employers.