The Bishopric of Würzburg shared its authority with the noblemen von Habermann until it was secularised in the year 1803 for the benefit of Bavaria.

In 1805 the area was exchanged with Tyrol and was conclusively incorporated into Bavaria in the year 1814 together with the tenurial of the von Habermanns.

Among the tens of thousands of Central European German-speakers who came to America in the 1840s and 50s were 15 Jews from Unsleben who founded the Jewish community in Cleveland, Ohio.

During the time of Nazi Germany, the local [[Jewish families were prosecuted, forced to emigrate or murdered.

As of 30 June 2010, according to the official statistics, 315 persons were employed in Unsleben, of which 139 in manufacturing, 111 in trade, transportation and hospitality industry, and 37 in public and private service providers.