The Hefei–Wuhan railway (simplified Chinese: 合武铁路; traditional Chinese: 合武鐵路; pinyin: Hé-Wǔ tiělù) is a 250 kilometres per hour (160 mph) high-speed railway in Chinese provinces of Anhui and Hubei, with trains running from Anhui's capital Hefei to Hubei's capital Wuhan.

The railway opened on 31 December 2008, high-speed services started on April 1, 2009.

As of July 2010, scheduling systems showed nine daily D-series express trains running in each direction between Hefei and Wuhan's three train stations (Wuhan, Hankou, and Wuchang), making the trip in 2 hours to 2 hrs 40 min.

Another six Shanghai-Wuhan D-series trains passed this section without stopping in Hefei.

The railway uses tunnels when crossing the Dabie Mountains on the Anhui–Hubei border.