It runs downhill from the western end and forms of the longer B519 that includes Highgate Hill towards Archway.
At its western end is a crossroads by The Gatehouse pub where it meets Hampstead Lane, Highgate West Hill and North Road.
Other roads running off the High Street include Southwood Lane and South Grove.
The High Street forms the border between the London Borough of Camden to the south and Haringey to the north, reflecting the historic parish boundaries between Hornsey and St Pancras.
[2] Highgate developed as a hamlet in the early fourteenth century by the arched gateway on a north–south toll road that gave the settlement its name.