Highway 12 is a single carriageway road in the South District of Israel.

It surrounds the mountains of Eilat from the north and west, and it connects Eilat to Highway 10 and Highway 40, which lead toward central Israel.

Highway 12 begins as an urban boulevard in Eilat exiting the city to the west.

Then it turns north past the Netafim Border Crossing and the northern mountains of Eilat.

It continues northeast past Ovda airport and reaches its north terminus at Shizafon junction, where it intersects with Highway 40.