Outside of the communities that it cuts through, the majority of surrounding land use is agricultural, though forest is dominant near the Moira River.

North of Highway 401, the route curves to the northeast, bypassing the communities of Cannifton and Corbyville.

At Roslin, the highway exits Belleville and briefly crosses into Centre Hastings, before straddling the boundary with Tweed north to Thomasburg.

It approaches Stoco Lake and turns north into the village of Tweed, where it is locally known as Victoria Street.

As part of the ensuing depression-relief project, over 2700 men blasted rock, dredged muskeg and endured a constant barrage of blood-sucking insects in order to construct the new highway,[6] which was opened to traffic on August 23, 1932.

[15] O'Brien's Bridge over Moira River south of Plainfield collapsed in spring of 1945 when a truck struck it.

[21] The interchange was rebuilt in 1991 as a parclo AB, with the ramps on the west side of Highway 37 being removed.

[20] The following table lists the major junctions along Highway 37, as noted by the Ministry of Transportation of Ontario.