In the past, it was an uninterrupted road from Netanya, a city on the Mediterranean coast in the west, to Damia Bridge across the Jordan River in the east.

Today, the road is separated into three unconnected parts: the first from Netanya to Nitzanei Oz interchange at Highway 6, the second from there to an Israel Defense Forces checkpoint in Beka'ot in the northeastern West Bank, and the third from there until Damia Bridge.

The western portion of Highway 57 is located entirely within Israel proper and crosses the narrow strip of land between the Mediterranean coast and the Green Line.

Today, continuing from Israel proper into Tulkarm is impossible because the Israeli West Bank barrier blocks the road.

[citation needed] The second portion of the route, from Tulkarm via Nablus to Beka'ot junction, is a continuous road with one carriageway.

It passes through Deir Sharaf, Beit Iba checkpoint and the center of the city of Nablus, based on the path of Nahal Shekhem.