[1][2] It runs between Regent Street at the junction with Lensfield Road and Gonville Place (the A603) to the northwest and a roundabout by the Cambridge Biomedical Campus, continuing as Babraham Road (also part of the A1307) to the southeast.
On the corner with Lensfield Road is Our Lady and the English Martyrs Church.
To the west of the road is the Cambridge University Botanic Garden.
The Cambridge Biomedical Campus is to the southwest of the roundabout at the southeastern end, at the edge of the city and houses Addenbrooke's Hospital.
The original hospital was located on the Old Addenbrooke's Site on Trumpington Street in central Cambridge.