[7] Hillsboro High School offers Advanced Placement classes, including United States Government and Politics, Macroeconomics, United States History, World History, Biology, Calculus AB, English Literature & Composition, and English Language & Composition.

The school also offers students an opportunity to enroll in courses at Southern State Community College for dual credit.

The school hosts a National FFA Organization chapter, as well as a Quick Recall (academic) team.

In performing arts, the school has an International Thespian Society chapter (Troupe #5928) for drama students.

The Symphonic Choir has won Superior ratings at state contest each year for more than a decade.